Schizophrenia is a very complex mental disease. It is actually quite possible that various… 1 answer below »
Schizophrenia is a very intricate hyperphysical malady. It is substantially entirely likely that uncertain mechanisms may end up supple alike symptoms. Several neurotransmitter schemes accept been implicated: dopamine, glutamate and GABA. Most of the hypotheses standpoint on synapses and receptors activated by those neurotransmitters.
Let us try to deem apart and overlook the receptors for the moment: what would betide if an grave inactivating scheme – such as glutamate enravishment in glial cells – was altered? How would it like glutamatergic neurotransmission? Could a peculiar variation in the look of a point glutamate enravishmenter expound signs and symptoms of schizophrenia? The publications listed under should produce requisite setting and appended references which should acceleration to response the aloft questions.
Bellesi M, Melone M, Gubbini A, Battistacci S & Conti F (2009) GLT-1 upregulation impairs prepulse discommend of the alarm reflex in adult rats. Glia 57 703-713
Kondziella D, Brenner E, Eyjolfsson EM & Sonnewald U (2007) How do glial-neuronal interactions fit into ordinary neurotransmitter hypotheses of schizophrenia? Neurochemistry International 50 291-301
Melone M, Bellesi M, Ducati A, Iacoangeli M, Conti F (2011) Cellular and synaptic colonization of EAAT2a in anthropological cerebral cortex. Frontiers in Neuroanatomy 4 10.3389/fnana.2010.00151.